Posted by megablogger at 6:06 PM. Placed in eHealth category
Recent scores for: Obesity connected to breast cancer mobile growth and tumor measurement
New study suggests that the weight problems status of a woman might establish the price of breast cancer cell progress and tumor dimensions. This is according to a examine printed in the journal Breast Cancer Research.
Being overweight is recognized to be a significant danger factor for breast cancer in put up-menopausal women, say researchers from the Tulane College of Drugs in New Orleans, LA.
In accordance to a earlier research released in JAMA of more than 80,000 registered nurses, females who obtained 55 pounds or more following the age of eighteen have been identified to have a 50% increased chance of creating breast most cancers.
But the scientists notice that being overweight, notably abdominal weight problems, and its romantic relationship with excess fat stem cells and breast most cancers has not beforehand been researched.
Consequently, the investigation team analyzed a series of fat stem cell lines that experienced been taken from 24 women who were going through elective liposuction.
One particular stem mobile line from every single woman was taken from the stomach, whilst one more was taken from a non-abdominal area. For comparison, cells ended up taken from the two overweight and non-obese females, as established by their physique mass index (BMI).
The body fat stem cells ended up developed in a laboratory alongside breast most cancers cells. These cells had been then injected into the mammary glands of mice, and an estrogen pellet was placed beneath their skin.
Obesity ‘increases expression of leptin’
On inspecting the tumor development from the samples, the researchers discovered that the cells taken from females who were obese elevated most cancers mobile figures and tumor progress, and this detection was much more important in cell strains taken from abdominal body fat.
The researchers say that this finding may possibly be owing to the publicity of the fat cells to estrogen. They say that this boosts the generation of a hormone referred to as leptin, which increases the number of cancer cells and tumor progress.
Describing the conclusions, Bruce A. Bunnell, a senior author from the Middle for Stem Mobile Analysis and Regenerative Medicine and the Division of Pharmacology at Tulane University, advised Health care News Right now:
“It was decided that weight problems alters the stromal cells (connective tissue cells of organs) and will increase their expression of leptin.
Functionally, the altered stromal cells influence proliferation via a number of important molecular aspects. With each other, this would propose that being overweight alters stromal cell function, which in flip alters breast most cancers cells to increase their growth and development.”
Likely targets for therapeutic intervention
Bunnell extra that these conclusions are essential, as they provide proof to assist the role of weight problems at the “cellular and molecular stage” in breast most cancers growth and development.
“Even though earlier epidemiological research have demonstrated a hyperlink, we are 1 of the very first to display the effects of altered stromal cells on the gene signature of breast cancers cells,” Bunnell instructed Health-related News These days.
“Furthermore, by determining the distinctions amongst the stromal cells from obese females and lean ladies, we may be capable to discover novel targets for therapeutic intervention.”
Bunnell observed that these results ought to prompt girls, specifically individuals who are at higher threat of breast most cancers, to preserve a healthful entire body fat. He referred to preceding studies, in which females who ended up enrolled in a strict diet program and physical exercise routine had a better breast most cancers prognosis, when compared with females who did not follow the routine.
The subsequent step from this analysis, Bunnell explained, is to determine the approach by which obesity alters stromal cells.
“Whilst we know that being overweight prospects to long-term, lower-grade irritation, pinpointing the particular mechanisms associated may help us limit the results on the stromal cells and in switch the help these cells provide to the tumor,” he extra.
“In addition, determining whether or not these leptin-altered stromal cells affect other aspects of breast most cancers will be exciting to look into. The final results will supply additional proof for the mechanism by which being overweight boosts breast most cancers incidence and mortality.”
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Recent rankings for: Review of ‘sister’ stem cells uncovers new most cancers clue
Researchers have utilized a manufacturer new approach for analyzing individual stem cells to uncover remarkable distinctions in the gene expression ranges – which genes are turned ‘up’ or ‘down’ – in between apparently equivalent ‘sister’ pairs.
The study, printed in Stem Mobile Reports, was carried out and funded by The Institute of Most cancers Analysis, London. It provides the most recent proof that despite possessing identical DNA, sister stem cells can show substantial variances in their molecular attributes.
The study showed that DNA methylation, a method that controls which genes are expressed in cells, performs an critical position in creating non-genetic (or ‘epigenetic’) variations among sister cells.
DNA methylation could for that reason be 1 of the reasons for the main molecular variation among various most cancers cells in the very same tumour – and medicines to lessen methylation may well help control variation and make cancers easier to deal with.
In the new research, experts at The Institute of Cancer Study (ICR) developed a novel micro-dissection technique to individual pairs of sister embryonic stem cells for one mobile RNA investigation [one].
Utilizing their new higher-tech approach, researchers separated and isolated mouse stem cells from their sister pairs and measured the conduct of important genes recognized to be expressed in those cells. By comparing which of these genes had been up – or down – controlled, they decided the ranges of similarity amongst sister cells at the molecular amount for the very first time.
They found that under normal situations, pairs of sister stem cells displayed considerable variations to each and every other, displaying nearly as a lot variety as two cells from diverse sister pairs.
The researchers then appeared at cells developed in the presence of a chemical cocktail referred to as 2i, which reverts cells again to their most primitive stem cell condition where they can make similar copies of on their own. They found that the cells had reduced ranges of two enzymes essential for DNA methylation and they produced more similar sister cells.
The outcomes advise that DNA methylation is a major trigger of the variety between sister cells when they divide.
Dr Tomoyuki Sawado, chief of the Stem Cells and Chromatin Crew at The Institute of Cancer Study, said: “Embryonic stem mobile division is generally considered to be a symmetrical approach, but what we located was that sister cells are truly usually really diverse from one another.
“We used a new approach to separate paired stem cells blended with assays that measure RNA in personal cells. Our investigation showed that sister stem cells exhibit substantial distinctions in which genes are expressed. These distinctions are useful for normal stem cells in their consistently altering setting, and in cancer cells, the exact same attributes can permit them to evade treatment options. If we can control a method like DNA methylation that generates variety in cell populations, we could create far more efficient remedies for most cancers.”
Professor Mel Greaves, Professor of Cell Biology at The Institute of Cancer Research, explained: “How stem cells control expression of their genes is crucial to several basic biological processes, these kinds of as embryonic growth, regeneration and turnover of blood, skin and other tissues in the body, but specially to most cancers.
“One particular of the most significant problems in cancer therapy is overcoming drug resistance. Research from the ICR has exposed that the cells of personal tumours are remarkably diverse and this new investigation highlights one particular way this may possibly be achieved. The inherent variability of cancer mobile populations provides them with the versatility to adapt and survive even when confronted with progressive new medicines. If we could harness these new insights to prohibit the diversity of most cancers cells it would considerably increase the potential customers for effective control or eradication of cancer.”
Post tailored by Healthcare Information Right now from original press release. Click ‘references’ tab above for source. Check out our stem cell study section for the newest news on this subject matter.
 Single cell RNA examination is the investigation of an person cell’s gene expression profile to establish which genes have been expressed.
Sawado et al., Determining division symmetry of mouse embryonic stem cells: adverse effect of DNA methyltransferases on symmetric self-renewal.
Stem Mobile Reports, 2013, http://dx.doi.org/10.1016/j.stemcr.2013.08.005
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Posted by megablogger at 2:04 PM. Placed in eHealth category
Main Class: Conferences Write-up Day: twenty five Sep 2013 – five:00 PDT
Existing scores for: One of the most basic modifications in the pharma business today to be discussed at Eyeforpharma Barcelona 2014, March, 18-twenty
Pharma Gathers to Examine ‘One of the Most Basic Changes in the Pharma Sector Today’
Associates from each international pharmaceutical firm including UCB, Novartis, Pfizer, Merck, Bayer and Grunenthal will obtain at an yearly industry summit to determine the potential of affected person-centric healthcare, which some believe to be the most basic adjust to the system in decades.
Billions of dollars are now currently being invested in patient-centric healthcare inside of the pharmaceutical business and broader health care landscape, delivering a clear demonstration that the time period is transferring beyond merely the most recent advertising and marketing ‘buzzword’ to become a elementary pillar in the future of health-related remedy.
Speaking to eyeforpharma forward of the yearly three-working day summit in which industry leaders will satisfy to set the benchmark of the potential of affected person worth, Lode Dewulf, Chief Affected person Officer at UCB explained client-centric health care as “a single of the most basic changes in the pharma industry these days and in the potential”.
Above one thousand senior pharmaceutical and healthcare executives will attend the summit which will also be looking at developing value for your consumer in a few crucial places. Price Partnerships, Product sales Excellence and Multichannel Advertising and marketing, are these days virtually unrecognizable in contrast to business expectations as minor as two years ago, and are set to proceed to evolve at a exponential price in the coming years as the conditions ‘patient’ and ‘value’ seep in to every single facet of market exercise.
“The motion toward a a lot more enterprise and client concentrated technique inside of pharma continues and I will be searching to network with, and listen to from, like-minded folks who are determined to speed up their organisation’s progress. I hope to just take absent some key actions that will allow us to speed up and increase our overall implementation of an progressive new approach to our enterprise” mentioned Allan Waterproof coat of Grunenthal.
eyeforpharma Barcelona will be taking spot 18-20th March, 2014. For far more details on the summit, to see who else will be in attendance, or to locate out how this year’s agenda will impact your potential enterprise methods check out the official site.
Celebration: twelfth Yearly eyeforpharma Barcelona 2014 Dates: 18th – twentieth March 2014 Area: CCIB, Barcelona
For far more info speak to: Lucy Fisher EyeforPharma (+44) 207-375-7225 email@example.com
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Posted by megablogger at 2:56 AM. Placed in eHealth category
By Kathryn Doyle
NEW YORK (Reuters Wellness) – Expectant moms can use corticosteroid creams for irritated skin with no placing their fetus at threat, besides for massive quantities of extremely powerful creams, a new examine indicates.
In common, using individuals ointments throughout pregnancy was not joined to babies’ probabilities of possessing cleft palate, being born early or small or any other calculated damaging outcome, scientists identified.
That is not stunning and is in line with prior study, direct author Dr. Ching-Chi Chi of the dermatology section of Chang Gung Memorial Clinic in Chiayi, Taiwan, explained.
“This is not new information, however this write-up is reassuring to women who are utilizing some topical corticosteroids,” Dr. Heather Lipkind, an associate professor of obstetrics, gynecology and reproductive sciences at Yale College of Medicine in New Haven who was not involved in the new examine, instructed Reuters Wellness.
The scientists did uncover that when ladies employed much more than three hundred grams of very potent corticosteroids for the duration of pregnancy, infants were at improved danger of reduced birth weight, which is new, Chi explained.
Topical steroid creams are commonly approved for rashes, eczema or other skin irritation. Generic nonprescription kinds this kind of as Bactine are extremely lower energy, but prescription varieties can be minimal to substantial toughness.
Making use of United kingdom knowledge from 1989 to 2006, the researchers compared charges of beginning defects and supply difficulties amid infants born to about 2,seven-hundred girls who have been recommended a corticosteroid cream for the duration of being pregnant and individuals born to 7,two hundred females who did not use the medication.
General, 4.7 % of babies whose moms experienced employed corticosteroids have been minimal start bodyweight, when compared to four.8 % of those whose mothers did not use the lotions. Just below 1 per cent of both teams of toddlers had been born untimely, or ahead of 37 weeks’ gestation.
With powerful creams, babies’ risks also did not change when females utilized a total of one hundred to two hundred grams of the medication for the duration of their total pregnancy. But when moms-to-be utilised 300 grams – the quantity in six regular-dimensions tubes – or far more, the chance of reduced birth weight went up sevenfold.
The most potent topical lotions consist of clobetasol propionate, betamethasone dipropionate and fluocinonide (promoted as Vanos and Lidex) and are employed to treat significant irritation, itching or psoriasis.
Steroids dysregulate placental hormones and almost certainly stop important proteins from getting to the little one, Chi instructed Reuters Overall health.
In his team’s examine, ladies who utilised the ointments were also a lot more probably to have asthma and to take other large-risk medications throughout pregnancy than those who did not.
Skin irritation, discoloration and thickening are common during being pregnant, and corticosteroid creams are recommended to about 6 percent of pregnant women, the scientists wrote in JAMA Dermatology.
Recent guidelines advise mild- or average-toughness lotions for pregnant females except if strong creams are completely essential, which this study supports, Chi said.
If potent drugs are necessary, medical doctors ought to keep an eye on the development of the fetus, he added.
“We would not advise pregnant ladies end utilizing topical steroids just due to the fact of exaggerated dread of the prospective facet effects,” Chi explained. “We stimulate ladies to implement topical steroids appropriately underneath physicians’ direction, which would treat skin conditions effectively and increase pregnant women’s existence quality.”
Supply: http://little bit.ly/1g0WJps JAMA Dermatology, online September 4, 2013.
Neurosurgeons from the University of California, San Diego (UCSD) have executed the very first real-time MRI-guided gene therapy for individuals with brain most cancers, advancing the medical demo of new most cancers drug, Toca 511.
The new treatment, carried out by neurosurgeons at the UCSD Faculty of Medicine and the UCSD Moores Most cancers Heart, utilizes true-time magnetic resonance imaging (MRI) as a way of guiding the delivery of the new gene remedy right into brain tumors.
MRI navigational technologies, referred to as Clearpoint, allows the neurosurgeons to inject Toca 511 (vocimagene amiretrorepvec) right into a mind tumor.
Adhering to our before information tale Brain cancer: groundbreaking MRI-guided gene treatment, Clark Chen, chief of stereotactic and radiosurgery and vice chairman of neurosurgery at the University of California, San Diego, has spoken solely to Healthcare Information Nowadays about how the MRI-guided gene treatment performs, and what this implies for the potential of mind cancer remedy.
How does the MRI guided gene treatment work?
Preceding endeavours with gene remedy for brain most cancers have been mainly constrained by the incapability to supply the drug into the mind. Under typical conditions, the mind is protected by a physiological system called the blood-mind barrier.
Sadly, this all-natural protection mechanism also prevents drugs from achieving the cancer cells in brain tumor clients. It is believed that much less than 1% of all accessible medicines will cross the blood brain barrier.
We by-handed the blood mind barrier by right injecting the gene remedy into the region of the tumor.
To guarantee that the adequate amount of agent is sent to the location of the tumor, we utilized a state-of-the art MRI technology to check the shipping and delivery and injection processes in genuine time.
The MRI-guided method offers visual affirmation that ample amount of the remedy is delivered into the tumor. In addition, the capability to visualize the shipping catheter in true-time helps prevent any unintended harm to the brain.
What are the benefits and dangers of utilizing this treatment method?
To recognize the positive aspects of the remedy, we 1st need to have to review the basis of the gene therapy. The gene treatment is primarily based on a retro-virus engineered to selectively replicate in high grade mind most cancers cells.
This virus generates an enzyme that converts the Food and drug administration approved anti-fungal drug flucytosine (five-FC) into the anti-cancer drug five-fluorouracil (five-FU).
Following the injection of the virus, the sufferers are taken care of with oral formulations of 5-FC. Tumor destroy is induced when five-FC comes into get in touch with with cells infected with virus.
Generally, when chemotherapy is presented, just about every mobile in the body is uncovered to the potential aspect-consequences of the drug. The direct injection approach restrictions the presence of the energetic drug in the brain tumor and not elsewhere in the body. Therefore, the technique guards the client from several of the supposed facet-outcomes of chemotherapy.
The virus has been tested in a big quantity of patients and has been shown to be safe. So the hazards of the treatment relates to the surgical treatment by itself.
The MRI technological innovation makes it possible for the surgeon to visualize the supply catheter in true-time. In carrying out so, the surgeon can stop any unintended injury to the mind throughout the method. So, the threat of the process is reduced to an complete minimal.
All of my clients going through this treatment had been discharged from the hospital a single working day soon after surgery and resumed their regular day-to-day action thereafter.
How will this modify the future of mind most cancers treatment?
Due to the fact of the blood mind barrier, when a drug fails to avoid the tumor from expanding, it is in no way distinct whether the drug failed since it in no way got to the tumor or because the drug got to the tumor but has no influence on the tumor.
With the MRI-guided injection technique, we can now get started to reply this issue. If the tumor grows again in the area in which the virus was injected, then we want to develop far better viruses.
Nonetheless, if the tumor grows only in locations exactly where the virus was not injected, then we require to build much better approaches of injecting the virus in a greater location of the mind. So, the final results of this trial will basically dictate the proper subsequent stage in conditions of therapeutic improvement.
Can you see this new strategy becoming commonly employed?
Yes. Due to the fact the technique by-passes the blood mind barrier and any drug or gene treatment can be injected under MRI advice, the approach effectively expands the spectrum of medicines that we can use to handle mind cancers by a hundred fold.
The far more medications that we have available from brain most cancers, the nearer we will go towards curing this ailment. For this reason, I believe that this method will turn into more broadly utilized.
Job interview with Honor Whiteman
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Posted by megablogger at 10:42 PM. Placed in eHealth category
(NaturalNews) Last week, Detroit declared bankruptcy, becoming the largest city in U.S. history to take such drastic action in the face of financial insolvency. A declaration of bankruptcy isn’t what most people think it is, though: it’s not just a statement of “we’re broke!” It’s actually a way for the city to clear its slate of all financial obligations and not pay the retirees it owes.
What are the largest financial obligations the city facing? Pensions. $ 3.5 billion worth of pensions, to be exact.
Yes, Detroit owes former government employees — teachers, firefighters, cops and more — a whopping $ 3.5 billion in current and future payments. Except Detroit doesn’t have $ 3.5 billion to pay the pensions. The city is in a state of economic collapse. Remember, the U.S. government used billions in taxpayer money to help General Motors move its manufacturing offshore to countries like China. As a result of economically-insane actions and criminal mismanagement, a city that used to be the hub of industrial output in America has become a ghost town of abandoned buildings, crumbling infrastructure and financial destitution.
But even as all this was becoming apparent, the government workers there continued to collect fat paychecks and pensions, all based on the promise that endless population growth would out-pace the rise in pension obligations. Many pensioners are owed over $ 100,000 a year from the government, and this is true across California, Illinois and many other states as well.
Chicago, for example, owes $ 19 billion in pension payments that it doesn’t have, and the city of Los Angeles is more than $ 30 billion in the hole. The story is much the same in every major U.S. city.
Early this year, the Pew Center released a survey showing that 61 of the nation’s largest cities — limiting the survey to the largest city in each state and all other cities with more than 500,000 people — had a gap of more than $ 217 billion in unfunded pension and health care liabilities. While cities had long promised health care, life insurance and other benefits to retirees, “few … started saving to cover the long-term costs,” the report said.
Realizing it flat-out doesn’t have the money to pay these pension obligations, Detroit had little choice but to declare bankruptcy in an effort to avoid paying the pensions. In effect, this is a confiscation of all pension funds by the government, meaning that retired cops, firefighters, school teachers and so on will never see a dime of the pensions they thought they had earned.
Naturally, those who are owed the pensions are furious about all this. Imagine working 40 years on the job, building up a retirement only to have that retirement stolen from you by a local government that’s steeped in corruption and financial mismanagement. The word “incompetent” doesn’t even begin to describe Detroit’s political leadership. It’s more like “brain damaged” or “criminally insane.”
But it’s also commonplace. Across the country, city governments have all spent the pension funds instead of saving them. Almost no large city has the funds necessary to pay its obligations to retirees. Pension financial planning strategies are tragic nightmares of broken promises, dishonest politicians and delusional workers (who still somehow believe they’re going to get paid).
In Detroit, the pensioners are fighting back, claiming Michigan’s state constitution forbids cities like Detroit from wiping away pension obligations by declaring bankruptcy. It’s all headed to the courts now, where even if Detroit’s bankruptcy is nullified, the city still doesn’t have the money to pay its pension obligations.
So it’s a no-win situation regardless of the outcome. Where the money doesn’t exist, nobody gets paid regardless of the legal wrangling in the courts.
There’s already talk of Obama bailing out Detroit, meaning the federal government would take on the debt of the mismanaged city and its pension funds, eventually passing on those obligations to taxpayers all across the country.
Yep, that means you and I will be paying the $ 100,000 retirement pension of some ex-cop in Detroit. It’s all part of the federal government’s new plan to reward waste and punish fiscal responsibility.
No wonder Sen. Rand Paul says Detroit will only be bailed out “over my dead body.” As Breitbart.com reports, Sen. Paul has stated, on the record, “I basically say he [Obama] is bailing them out over my dead body because we don’t have any money in Washington.”
Breitbart.com goes on to state, “Paul said the reason he is going to fight to stop any efforts to bail out Detroit is that if the president succeeds in bailing it out, that will send a signal to the rest of cities and states nationwide that the federal government will bail them out to if they conduct reckless spending.”
“Those who don’t have their house in order, who are teetering on disaster, will continue to make bad decisions.” – Sen. Rand Paul.
He’s right, of course. But rewarding reckless spending has become the new sport in Washington, where globalist banks routinely receive hundreds of billions of dollars in taxpayer bailouts after losing money on outlandish derivatives bets that went sour.
If we bail out Detroit, then the precedent is set: The taxpayers will have to foot the bill to bail out Chicago, Los Angeles, New York, Phoenix, Seattle and every other city that’s on the brink of financial disaster because bureaucrats are short-term thinkers who typically only think ahead to the next election, not the next generation.
“Public pension plans across the nation are in fiscal distress. Generally underfunded, most now require far greater contributions from governments than initially envisioned,” writes the California Common Sense organization, which goes on to state:
In 2012-13, Los Angeles’s pension costs are expected to rise to $ 1.3 billion, or 18% of the city’s budgeted expenditures. In 2002-03, just 10 years ago, pension costs were only $ 157 million, or 3% of total expenditures. Over the last decade, pension costs have grown at an annual average growth rate of 25% and have outpaced spending growth for every major area of the city’s budget.
“In April Moody’s Investors Service warned it could downgrade the ratings of Chicago, Cincinnati, Minneapolis, Portland and 25 other local governments and school districts as part of a change in how it factors public pensions into debt grades,” writes Forbes.com. “In Chicago, teachers’ pensions alone cost $ 1 billion a year, while overall debt service accounts for close to a quarter of the city budget.”
According to Business Insider, here are the top 10 U.S. cities whose pension obligations will soon collapse: (this article was originally published in 2010, so we have updated the “years” to reflect 2013)
#1 Philadelphia – Unfunded liability of $ 9 billion, $ 16,696 per household, only 1 year before the pension accounts are empty
#2 Chicago – Unfunded liability of $ 44.8 billion, $ 41.966 per household, money runs out in 4 years
#3 Boston – Unfunded liability of $ 7.5 billion, $ 30,901 per household, money runs out in 4 years
#4 Cincinnati – Unfunded liability of $ 2 billion, $ 15,681 per household, money runs out in 5 years
#5 St Paul – Unfunded liability of $ 1.4 billion, $ 13,686 per household, money runs out in 5 years
#6 Jacksonville – Unfunded liability of $ 4 billion, $ 12,944 per household, money runs out in 5 years
#7 New York City – Unfunded liability of $ 122 billion, $ 38,866 per household, money runs out in 6 years
#8 Baltimore – Unfunded liability of $ 3.7 billion, $ 15, 420 per household, money runs out in 7 years
#9 Detroit – Unfunded liability of $ 6.4 billion, $ 18,643 per household, money runs out in 8 years
#10 Fort Worth – Unfunded liability of $ 2 billion, $ 7,212 per household, money runs out in 8 years
Note that some of these numbers were actually optimistic. Detroit, for example, was predicted to run out of money in 2021, yet it already declared bankruptcy in 2013. What you are looking at here is a looming cascade of municipality bankruptcies over the next 10 – 20 years.
Nobody saves in America anymore; not cities, not states and of course not the federal government which Obama has brought to the astonishing debt level of $ 16 trillion (it was only $ 8 trillion when he first took office). It begs the question: If the cities bail out the pensioners, and Washington bails out the cities, who’s going to bail out Washington and its exploding debt?
The answer, of course, is nobody. Central banks all around the world are already sitting on far too much U.S. debt that’s being eroded by the hour as the Federal Reserve commits “quantitative easing” that dilutes the global dollar supply. They aren’t going to take on trillions more to bail out a nation now seen as a global imperialist bully that runs NSA spying on its own allies while routinely engaging in economic espionage through currency manipulations.
The American government is widely hated throughout the world today. Most nations probably wouldn’t mind seeing the USA collapse into financial oblivion. And within a few years, they may just get their wish.
“On average, pensions consume nearly 20 percent of municipal budgets,” writes Anthony Flint of The Atlantic Cities. “But if trends continue, over half of every dollar in tax revenue would go to pensions, and by some estimates in some cases would suck up 75 percent of all tax revenue.”
The upshot of all this is that if you are counting on a government pension to pay your bills during your retirement years, you may need to write that off because it probably won’t be there for very much longer.
This is true not just for local and state government workers, but also for federal government workers. Yep, all those TSA agents, DHS workers and FDA bureaucrats are going to see their own pensions stolen, and I can’t say that I’m shedding tears over TSA goons not getting their pensions. (“Pedophilia pensions!”)
“I mean the statistics in California are staggering,” said Sen. Rand Paul. “I think there’s over 100,000 people there getting over $ 100,000 a year in retirement. You got police chiefs in medium-sized cities getting $ 350,000 a year for a salary. It’s become untenable. But the main thing is we cannot send a signal from the federal government that cities and states are going to be too big to fail.”
Where all this really hurts, though, is at the local level. In most cities, people like firefighters, cops and school teachers are wildly under-paid. They dedicate their lives to serving the community, often putting their own lives at risk in the process. Stealing their pensions is especially malicious given how much they have sacrificed to earn them.
But there’s nothing that can be done to save them at this point. The mathematics are already in motion and unstoppable. Nearly all big-city pension obligation projections have been based on the false assumption that endless economic growth would provide a never-ending tax base from which pension obligations could be paid. That assumption, however, was a willful delusion in which city managers and bureaucrats happily engaged.
There is a day of reckoning coming for America, and it’s going to be a day of nationwide outrage as pensions all across the country are confiscated or destroyed in a cascading chain of bankruptcies. At the same time, the federal government will no doubt embark on a Cyprus-style private bank account confiscation program that steals private wealth from the American people. Wiring money out of the country will be made illegal, and all forms of wealth — including retirement accounts — will be subject to government confiscation.
At that point, only people who have gone to great lengths to protect their assets will have anything left. What holds value in such a scenario? Land, bullets, rifles, hand tools, stored food, silver coins, gold coins, iodine disinfectants and antibiotics, to name a few obvious items. Skills and education also rank high.
Detroit’s bankruptcy tells us the era of financial demise has begun. Now it’s only a matter of time before what happened to Detroit spreads to Los Angeles, Chicago, Philadelphia, Boston and other large U.S. cities. It is no coincidence that DHS and the feds are now routinely running paramilitary police state training exercises in high-density urban areas.
For the real story on all this, take everything you’ve just read about unfunded pensions and dig that hole ten times deeper. Because the unfunded health care obligations are ten times worse.
According to the Pew research document at www.Pewstates.org , a fiscal assessment of 61 large U.S. cities revealed that while pensions are 74% funded, retiree health care liabilities are only 6% funded.
You read that correctly: cities have only saved 6 cents on the dollar for what they’re going to need to pay the health care costs of retirees. And that’s assuming health care costs don’t keep skyrocketing thanks to hare-brained monopoly programs like Obamacare which lock in guaranteed monopolies to the drug companies, cancer centers and hospitals that now extract nearly one out of every four dollars of economic activity generated in across America.
Here’s the chart:
What this means in reality is that health care obligations will have to be abandoned. So at the same time cities confiscate pension funds, they will also abandon health care obligations.
For many retirees, this means they will lose their pensions and their health care benefits at the same time.
Law-enforcement agencies across the U.S., at every level of government, have been blurring the line between police officer and soldier. Driven by martial rhetoric and the availability of military-style equipment — from bayonets and M-16 rifles to armored personnel carriers — American police forces have often adopted a mind-set previously reserved for the battlefield.
This also tells you why government is secretly begging for a mass pandemic to wipe out all the elderly people in America: it would save cities and states from bankruptcy! No wonder government loves to promote Big Pharma — it’s the fastest way to kill people off and therefore not have to pay their retirement benefits. Longevity is the enemy of government because the longer you live, the more you collect in benefits. The sooner you die, the more you help government meet its unfunded financial obligations.
I wouldn’t be surprised to find the White House one day running a new public relations campaign with the message “Kill yourself. It’s good for America.”
Or “Suicide is patriotic.”
Sources for this story include: 1) My memory, experience, observations and reasoning.
About the author: Mike Adams is an award-winning journalist and holistic nutritionist with a passion for sharing empowering information to help improve personal and planetary health He has authored more than 1,800 articles and dozens of reports, guides and interviews on natural health topics, and he has published numerous courses on preparedness and survival, including financial preparedness, emergency food supplies, urban survival and tactical self-defense. Adams is a trusted, independent journalist who receives no money or promotional fees whatsoever to write about other companies’ products. In 2010, Adams created TV.NaturalNews.com, a natural living video sharing site featuring thousands of user videos on foods, fitness, green living and more. He also launched an online retailer of environmentally-friendly products (BetterLifeGoods.com) and uses a portion of its profits to help fund non-profit endeavors. He’s also the founder of a well known HTML email software company whose ‘Email Marketing Director’ software currently runs the NaturalNews subscription database. Adams volunteers his time to serve as the executive director of the Consumer Wellness Center, a 501(c)3 non-profit organization, and regularly pursues cycling, nature photography, Capoeira and Pilates. Known by his callsign, the ‘Health Ranger,’ Adams posts his missions statements, health statistics and health photos at www.HealthRanger.org
Current rankings for: Researchers Aiming To Suppress Remedy Resistance In Brain Cancer
Gliomas are malignant brain tumors that occur from glial cells referred to as astrocytes, discovered in the central nervous system. “In dealing with malignant gliomas, we presently merge radiotherapy with the anticancer drug temozolomide. Nevertheless, in some sufferers, tumors rapidly become resistant to both therapy strategies,” states neurooncologist Professor Dr. Michael Platten, who leads a cooperation unit of the German Cancer Study Centre (Deutsches Krebsforschungszentrum, DKFZ) and the Department of Neurooncology of Heidelberg University Medical center. “We for that reason urgently need new approaches of dealing with these conditions much more effectively.”
Chemotherapy and radiotherapy damage the DNA of tumor cells. Usually these DNA problems immediately bring about the cellular suicide software acknowledged as apoptosis. Even so, tumor cells possess an effective DNA mend system that they use to shield by themselves from the repercussions of remedy, as a result evading mobile death.
Crucial repair mechanisms in the cell can only perform proficiently if a molecule referred to as NAD+ is existing. When DNA mend is operating at complete throttle, as is the case for the duration of radiation remedy, NAD+ provides are swiftly exhausted in a cancer cell, top to DNA damage that goes unrepaired and eventually cell death. Cancer researchers are as a result attempting to use drugs to deprive cells of NAD+ to stop resistance to therapies. Substances that inhibit the enzyme which produces NAD+ are previously being tested in medical trials.
Even so, cells can create NAD+ in a quantity of ways. They can synthesize it directly, or use a compound known as quinolinic acid, a metabolite of the protein developing-block tryptophan, as an option resource to create NAD+. Michael Platten and his crew had uncovered that malignant gliomas contain massive amounts of quinolinic acid. “We desired to know regardless of whether gliomas might use this circuitous route in get to produce enough NAD+ and thus escape treatment,” states neuropathologist Felix Sahm, very first creator of the publication.
If immediate NAD+ production is blocked, malignant glioma cells, unlike regular astrocytes, improve creation of QRPT. This enzyme breaks down quinolinic acid into NAD+. Therapies involving the anticancer drug temozolomide, radiation, or oxidative stress ended up found to guide to enhanced stages of QRPT in tumors. The greater the diploma of malignancy of the gliomas that were investigated, the far more QRPT they contained. Mind tumors that recurred right after merged radiotherapy-chemotherapy had a poorer prognosis when the most cancers cells produced substantial amounts of quinolinic acid.
The researchers also discovered that the tumor cells are not able of forming quinolinic acid on their personal. As an alternative, the compound is made by immune cells named microglia, which migrate in big quantities into gliomas. Microglia cells might constitute up to fifty percent of the complete mobile articles of a glioma.
In these circumstances, only the tumor cells have QRPT healthier astrocytes do not. That’s why only the tumor cells are able of breaking down quinolinic acid into NAD+. “The malignant transformation of astrocytes seems to be linked to their ability to use quinolinic acid as an different supply of NAD+ and therefore create resistance from radiotherapy and chemotherapy,” states Michael Platten. “A url in between microglia and the malignancy of gliomas has been identified for some time – now we may possibly have located a possible cause. The important enzyme for the alternative NAD+ source is QRPT. An agent directed against this enzyme may well assist suppress therapy resistance in brain most cancers. This may well allow us to obtain far better results in dealing with malignant mind tumors utilizing current strategies.”
Article adapted by Health-related Information Nowadays from authentic press launch. Simply click ‘references’ tab previously mentioned for resource. Pay a visit to our most cancers / oncology part for the newest news on this subject.
Felix Sahm, Iris Oezen, Christiane A. Opitz, Bernhard Radlwimme5, Andreas von Deimling, Tilman Ahrendt, Seray Adams, Helge B. Bode, Gilles J. Guillemin, Wolfgang Wick and Michael Platten: The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress. Cancer Investigation 2013, DOI: 10.1158/0008-5472.CAN-12-3831
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Helmholtz Association of German Analysis Centres. “Scientists Aiming To Suppress Therapy Resistance In Mind Most cancers.”Health care Information Today. MediLexicon, Intl., 29 Jun. 2013. Internet. 29 Jun. 2013. <http://www.medicalnewstoday.com/releases/262571.php>
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Current scores for: Most cancers-Evidence “Goo” From Bare Mole Rats May Direct To New Therapies
In spite of its lengthy lifespan, the naked mole rat has never ever been recognized to get cancer. Now researchers in the US have
uncovered this is thanks to a basic chemical in the “goo” of the rodent’s pores and skin, which they propose could lead to new anti-most cancers
therapies in people.
The group, led by Andrei Seluanov and Vera Gorbunova from the University of Rochester, New York, report their results in the 19
June on the internet concern of Mother nature.
The Naked Mole Rat
A native of East Africa, the naked mole rat (Heterocephalus glaber) is a little, short-sighted, hairless, creature that lives
in underground colonies with a social construction like that of bees: every colony has a solitary breeding queen.
A curious reality about the bare mole rat is that it lives for about 30 many years and never receives cancer. This is exceptional for a rodent:
consider mice, for instance, they dwell for around 4 a long time and typically die of most cancers.
The bare mole rat has numerous other uncommon features: it doesn’t control its physique temperature like other mammals, and it doesn’t
feel discomfort when its pores and skin is uncovered to acid or the melt away of chilli pepper.
These are some of the several issues that helps make the naked mole rat exciting to examine in the lab.
Earlier Review Recognized Gene that Helps make Bare Mole Rats Most cancers-Resistant
They discovered that the mole rat’s cells categorical a tumor suppressor gene named p16 that stops them proliferating when too a lot of are
crowded with each other. The result is to minimize off runaway expansion, the trademark of cancer, before it commences.
The result of p16 is so powerful, that when the group mutated the cells to induce a tumor, their growth barely transformed. Nevertheless when
they did the identical with mouse cells, these turned fully cancerous.
Pores and skin Goo of Bare Mole Rat Consists of HMW-HA
A certain feature that caught the attention of Seluanov and Gorbunova when they labored with skin cells from naked mole rats,
was that they oozed a gooey substance. It experienced an annoying inclination to clog up vacuum pumps and tubing. Also, when developing
skin cells in tradition, the ones from naked mole rats were viscous, unlike cells from people, mice, and guinea pigs.
Seluanov suggests in a assertion:
“We required to realize what the goo was.”
They identified that the goo is prosperous in a sugary substance named higher molecular fat hyaluronan (HMW-HA).
HA helps make tissue supple and helps the healing approach. The researchers speculate the mole rats developed high ranges of HA to
give their skin the elasticity it demands to accommodate lifestyle underground.
And provided the creature’s popularity for becoming cancer-resistant, they made the decision to test the position HMW-HA may well enjoy in that.
Anti-Cancer Qualities of HMW-HA
The group discovered when they taken off HMW-HA from bare mole rat cells, they turned inclined to tumors, suggesting the
chemical performed a position in generating them cancer-resistant.
And, relating back to their preceding perform when they determined the anti-cancer gene p16 in naked mole rats, the staff located that HMW-HA triggers the anti-cancer reaction of p16.
They also discovered that a gene called HAS2 is liable for making HMW-HA in the naked mole rat. Other animals also have
HAS2 but the gene works in a different way in the mole rat.
The staff now would like to examination HMW-HA in mice. If that goes nicely, they hope to consider it on human cells.
“You will find indirect proof that HMW-HA would perform in men and women,” says Seluanov. “It really is employed in anti-wrinkle injections and to relieve
soreness from arthritis in knee joints, with out any adverse effects. Our hope is that it can also induce an anti-cancer
“A great deal of cancer investigation focuses on animals that are prone to most cancers. We consider it’s possible to discover strategies for preventing
tumors by finding out animals that are most cancers-proof.”
Grants from the National Institutes of Overall health and the Ellison Health-related Foundation assisted pay out for the research.
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Paddock, Catharine. “Most cancers-Evidence “Goo” From Naked Mole Rats Could Guide To New Treatments.”Healthcare News These days. MediLexicon, Intl., 20 Jun. 2013. Net. twenty Jun. 2013. <http://www.medicalnewstoday.com/content articles/262236.php>
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Customer Views (newest revealed initial)
posted by Adam Austin on twenty Jun 2013 at 6:34 am
The common human has around 15 grams of HA in their entire body at any offered time, and HMW-HA is currently utilised in humans to reduce soreness in the knees of arthritis patients and in anti-wrinkle injections
‘Cancer-Evidence “Goo” From Bare Mole Rats May Lead To New Treatments’
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Posted by megablogger at 10:05 PM. Placed in eHealth category
Showcased Report Educational Journal Main Category: Breast Most cancers Report Date: 03 Jun 2013 – eleven:00 PDT
Current scores for: We Need Much more Breast Most cancers Trials For Young Patients Urge Professionals
The poorer survival rates of youthful breast most cancers sufferers could be a consequence of inadequate scientific trials for this age
group. This was a conclusion of a key new Cancer Study United kingdom study released online not too long ago in the Journal of the
Nationwide Cancer Institute (JNCI).
Senior creator Dianna Eccles, who heads Cancer Investigation UK’s Southampton Scientific Trials Unit, claims in a statement:
“This study adds to the evidence that breast cancer can behave really in different ways when diagnosed in youthful females.”
“They might need a distinct strategy to therapy – which just isn’t essentially comprehended from most cancers trials in more mature sufferers,” she
points out, urging that much more trials ought to be done in young females as “study is the essential to improving survival” for this group
and for creating new remedies particularly for them.
For the review, which was funded by Most cancers Research United kingdom and The Wessex Most cancers Believe in, Eccles and colleagues analyzed knowledge from
the Possible Research of Outcomes in Sporadic and Hereditary Breast Cancer (POSH), which was created to investigate variables
affecting prognosis in young breast most cancers patients, ie in between the ages of eighteen and forty.
Ladies beneath 40 symbolize much less than five% of breast cancers taken care of in the British isles. It is considerably more typical for the illness to be
identified in ladies who have handed the menopause.
Almost 3,000 individuals aged 40 and under (median age 36) joined the POSH examine at 127 British isles hospitals among 2000 and 2008,
exactly where details of tumor kind and qualities, ailment stage, therapy gained and final result had been recorded.
The outcomes show that the median tumor dimensions was 22 mm diameter and in fifty percent of the individuals the cancer had distribute to the lymph
A 3rd of the cancers were estrogen receptor (ER) unfavorable and nearly a quarter have been human epidermal growth factor receptor 2
Five 12 months survival was larger for clients with ER constructive breast cancers than for patients with ER adverse cancers.
But after five many years, there is a quick rise in relapse rates in clients with ER-good breast cancers who had the common treatment method: chemotherapy subsequent by tamoxifen for 5 several years.
This was “in contrast to individuals with ER-damaging breast cancers, where chance of demise peaked at two a long time”, publish the
The obtaining is also distinct to studies of more mature females that do not present the identical steep relapse fee after five many years.
Tamoxifen targets estrogen receptors to stop the hormone driving the cancer.
The researchers say if youthful patients were presented tamoxifen for more time, it may well support them, and these results demonstrate there is a
require to explore inquiries like this with trials that check various approaches particularly in young clients.
All round, breast most cancers patients face a drastically enhanced prospect of survival nowadays in comparison with many years back, claims Kate
Regulation, director of scientific research at Most cancers Analysis United kingdom.
But although now we can say usually that ladies today are “two times as likely to endure their condition for at the very least 10 several years
in comparison to those identified in the 1970s, the same can’t be stated for young breast most cancers patients,” she notes.
And, whilst new treatments are showing great assure in trials, specifically of new drugs named PARP inhibitors, specifically for
cancers induced by defective BRCA1 or BRCA2 genes in young women, “there is still so significantly much more we want to do to increase
therapy for young breast most cancers individuals and in the long run make sure that all ladies conquer their condition,” says Regulation.
Composed by Catharine Paddock PhD
Copyright: Health care Information Today
Not to be reproduced without permission of Healthcare Information Today
“Potential Observational Study of Breast Cancer Treatment Results for British isles Girls Aged 18–40 Many years at Prognosis:
The POSH Examine” Ellen Copson, Bryony Eccles, Tom Maishman, Sue Gerty, Louise Stanton, Ramsey I. Cutress,
Douglas G. Altman, Lorraine Durcan, Peter Simmonds, Gill Lawrence, Louise Jones, Judith Bliss, Diana Eccles, and POSH Study
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‘We Want Much more Breast Cancer Trials For More youthful Clients Urge Experts’
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Posted by megablogger at 8:09 AM. Placed in eHealth category
Primary Category: Lung Cancer Article Day: 01 Jun 2013 – :00 PDT
Present ratings for: Father And Son To Existing Their Respective Most cancers Analysis At ASCO
What started as a supper-table conversation in between a teen and his father has turn out to be a bonafide most cancers investigation study for Matthew Lara, a Davis Large College sophomore and the son of UC Davis Thorough Most cancers Centre healthcare oncologist and researcher Primo (Blessed) Lara.
Matthew, sixteen, will set on a match and existing his conclusions on non-tiny-mobile lung most cancers in the course of a poster session in Chicago on Saturday at the once-a-year meeting of American Society of Scientific Oncology (ASCO), a thirty,000-member cancer analysis organization.
Matthew’s poster, entitled “Predictors of survival for youthful clients significantly less than fifty years of age with non-modest cell lung cancer (NSCLC): a California Most cancers Registry investigation,” describes his results that youthful people with lung most cancers are likely to have much better survival rates than more mature individuals with lung cancer. His poster represents the largest analysis of age-relevant survival in lung cancer ever carried out. The perform was based mostly on info from the California Most cancers Registry, a massive, statewide repository for demographic and epidemiological cancer case info.
Primo Lara also will current analysis at ASCO on Saturday. His review – unrelated to Matthew’s function – analyzed survival variables related with tiny mobile lung cancer sufferers who experienced beforehand been handled with platinum-that contains chemotherapy.
Matthew’s venture was born at the meal table.
“We have been talking about lung most cancers, and I questioned my dad if youthful men and women get lung most cancers and if they do greater than older men and women,” mentioned Matthew. “My Father mentioned, ‘Well, you can certainly try out to uncover the response to that yourself!’ So we did.”
The two enlisted the aid of an analyst, statistician and epidemiologist as effectively as assistance from best lung cancer professionals at the UC Davis Extensive Cancer Middle. Matthew began with a database of 130,000 lung most cancers circumstances identified in California in between 1998 and 2009. The instances had been eventually narrowed to 108,062 instances of older sufferers (over fifty years of age) and 6,389 individuals more youthful than fifty.
Right after an epidemiological and demographic evaluation, Matthew and his co-authors identified a basic lower in the price of lung cancer diagnoses in young clients in excess of time. Among 1998 and 2001, for example, 37 % of lung cancers were located in younger clients compared to 29 per cent from 2006 to 2009. They also uncovered an 18 per cent reduction in the risk of loss of life in the sufferers who ended up diagnosed beneath age 50.
Because the Cancer Registry does not collect information on individual treatments or tumor phenotypes, Matthew stated one particular can only speculate about why the rate of lung most cancers among more youthful men and women has dropped and why young clients are inclined to do better than more mature individuals. He and his co-authors hypothesized that reducing smoking prices could be why there are less lung cancers in young folks more than time, and that youthful patients might have far better outcomes simply because they are much more very likely to have lung-most cancers types that react nicely to remedy.
“We are understanding about the important role of the immune program in preventing lung most cancers,” additional Karen Kelly, affiliate director for medical study at the most cancers heart, a lung cancer professional and a co-writer on Matthew’s poster. “Younger individuals might have a much more intact immune method.”
Kelly called the sixteen-calendar year-previous “a vivid student and budding researcher,” incorporating “I am certain Matthew has already considered of a number of concerns and is planning his following undertaking.”
Following Matthew’s study poster was accepted at ASCO, he gained a $ five hundred grant from the Davis Higher University Blue and White Basis to support his journey to Chicago, exactly where he will existing his poster to other oncology researchers Saturday morning.
Not surprisingly, soon after large university and school, Matthew hopes to comply with in his father’s footsteps as an oncologist and cancer researcher.
“There are so several individuals who nevertheless die from cancer,” he mentioned. “I want to recognize it greater, how it operates and how we can make it greater for individuals.”
Article tailored by Health-related Information Right now from authentic push launch. Simply click ‘references’ tab over for supply. Pay a visit to our lung most cancers segment for the newest news on this matter.
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University of California – Davis Well being Technique. “Father And Son To Present Their Respective Most cancers Research At ASCO.”Health-related News Right now. MediLexicon, Intl., 1 Jun. 2013. Web. one Jun. 2013. <http://www.medicalnewstoday.com/releases/261229.php>
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‘Father And Son To Current Their Respective Cancer Research At ASCO’
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